RESUMO
Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.
Assuntos
Anti-Inflamatórios/administração & dosagem , Estrogênios/metabolismo , Glucocorticoides/administração & dosagem , Osteoartrite/tratamento farmacológico , Perimenopausa/metabolismo , Administração Oral , Idoso , Anti-Inflamatórios/efeitos adversos , Comorbidade , Feminino , Glucocorticoides/efeitos adversos , Humanos , Pessoa de Meia-Idade , Osteoartrite/diagnóstico , Osteoartrite/metabolismo , Estudos Prospectivos , Fatores de Tempo , Resultado do TratamentoRESUMO
Resumen La infección por Clostridium difficile (cd) es una de la causas más comunes de diarrea adquirida en el ámbito hospitalario, y su espectro clínico puede ir desde casos leves, autolimitados, hasta situaciones como colitis de muy difícil manejo que pueden poner en riesgo la vida del paciente (1). Generalmente se ha asociado al uso crónico de antibióticos de amplio espectro (2). La incidencia de la enfermedad ha aumentado en los últimos años, haciendo que aparezcan nuevas opciones terapéuticas y diagnósticas a las ya conocidas. El objetivo de este artículo es hacer la revisión de un caso de un paciente con infección por cd documentada de difícil manejo, que respondió satisfactoriamente al manejo con rifaximine. (ActaMed Colomb 2013; 38: 177-181).
Abstract Infection with Clostridium difficile (CD) is one of the most common causes of diarrhea acquired in the hospital, and its clinical spectrum can range from mild, self-limiting cases to situations like colitis with difficult management that can put at risk the life of the patient (1). It has been generally associated with chronic use of broad spectrum antibiotics (2). the incidence of the disease has increased in recent years, causing the emergence of new therapeutic and diagnostic options different to those already known. the aim of this article is to review the case of a patient with documented cd infection with difficult management, that responded successfully to treatment with rifaximine. (Acta Med Colomb 2013; 38: 177-181).
